Dr. Keith Bonham

Selected Publications

Ritchie SA., Pasha MK., Batten DJP., Sharma RK., Olsen DDH., Ross ARS. and Bonham, K. (2003) Identification of the SRC Pyrimidine Binding Protein (SPy) as hnRNP K: Implications in the Regulation of SRC1A Transcription. Nucleic Acids Res. 31: 1502-1513. Pdf

Kostyniuk CL., Dehm SM., Batten D. and Bonham K. (2002) The Ubiquitous and Tissue Specific Promoters of the Human SRC Gene are Repressed by Inhibitors of Histone Deacetylases. Oncogene 21: 6340-6347. Pdf

Chen Z., Dehm S., Bonham K., Kamencic H., Juurlink B., Zhang, X., Gordon JR. and Xiang J. (2001) DNA Array and Biological Characterization of the Impact of the Maturation Status of Mouse Dendritic Cells on Their Phenotype and Antitumor Vaccination Efficacy. Cellular Immunology 214(1): 60-71. Pdf

Dehm S., Senger M. and Bonham K. (2001) SRC transcriptional activation in a subset of human colon cancer cell lines. FEBS Letters 487: 361-371. Pdf

Bonham K., Ritchie SA., Dehm SM., Snyder K. and Boyd FM. (2000) An Alternative Human SRC Promoter and its regulation by Hepatic Nuclear Factor-1a. J. Biol. Chem. 275: 37604-37611. Pdf

Rajala RVS., Dehm SM., Bi X., Bonham, K. and Sharma RK. (2000) Expression of N-Myristoyltransferase inhibitor protein and its relationship to c-Src levels in human colon cancer cell lines. Biochem. Biophys. Res. Commun. 273: 1116-1120. Pdf

Ritchie S., Boyd F.M., Wong, J., and Bonham K. (2000) Transcription of the human c-Src gene is dependent on Sp1, a novel pyrimidine binding factor SPy and can be inhibited by Triplex Forming Oligonucleotides. J. Biol. Chem. 257: 847-854. Pdf

Ritchie S. and Bonham K. (1998) The Human c-Src Proto-oncogene Promoter Contains Multiple Targets for Triplex Forming Oligonucleotides. Antisense and Nucleic Acid Drug Dev. 8: 391-400.

Aich P., Ritchie S., Bonham, K., and Lee, JS. (1998) Thermodynamics and Kinetic Studies of the Formation of Triple Helices Between Purine Rich Deoxyribo-nucleotides and the Promoter Region of the c-Src Proto-oncogene. Nucleic Acids Res. 26: 4173-4177. Pdf

Bonham, K. and Fujita, D.J. (1993) Organization of the 5' Noncoding Exons of the Human C-SRC Proto-Oncogene and Analysis of its Promoter Region. Oncogene 8: 1973-1981.

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